Kinases are vital proteins that can affect reaction stability, signal transmission, and protein activity and regulation. Basically they are involved in nearly all cellular pathways. There are numerous types of kinases existing throughout the body. When not functioning properly they can lead to cancer and other diseases. It has been long understood how to turn kinases on, but until University of Illinois at Chicago (UIC) scientists developed a new procedure, they weren’t able to be turned off. The novel procedure offers control over the kinase, switching them on and off.
Possible Implications and Findings:
Greater control and understanding of cellular pathways and molecular mechanisms
Prevention or treatment of cancer through targeted regulation of pathways and signaling
Identification of drug targets
Long-term cellular behavior effects of perpetual activation or brief activation of kinases.
UIC’s study, “Mimicking Transient Activation of Protein Kinases in Living Cells”, can be found in the Proceedings of the National Academy of Sciences.
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