Principal Investigator

Ready to shape the future of diabetes, obesity, and cardiometabolic research while leading groundbreaking clinical trials as a Principal Investigator?

R&D Partners is recruiting an experienced physician to join a research-focused organisation as a Principal Investigator in the United States. This opportunity offers the chance to provide medical leadership across a portfolio of investigational programmes, ensuring participant wellbeing, regulatory adherence, and scientific integrity while supporting the continued growth and development of research activities.

Applicants must have legal authorization to work in the United States.

Responsibilities:

• Act as Principal Investigator across a range of clinical studies focused on metabolic and endocrine disorders, including diabetes, obesity, lipid disorders, and cardiovascular risk management.
• Provide clinical oversight and scientific guidance throughout the conduct of research studies.
• Ensure participant safety, protocol adherence, and compliance with applicable regulatory requirements.
• Work closely with sponsors, contract research organisations (CROs), and study teams on trial feasibility and protocol review activities.
• Support the growth and development of therapeutic research programmes.
• Participate in investigator meetings, sponsor discussions, and study start-up activities.
• Assist with recruitment initiatives and strategies to optimise participant enrolment.
• Share medical expertise with internal stakeholders and external partners as required.
• Collaborate with operational, commercial, and patient engagement teams to support study delivery.
• Maintain compliance with FDA regulations, ICH-GCP guidelines, and site SOPs.

Key Skills and Requirements:

• MD or DO with a current and unrestricted medical licence.
• Board certification in Endocrinology, Internal Medicine, or a related medical specialty.
• Experience managing patients with metabolic, endocrine, or cardiovascular-related conditions.
• Previous involvement in clinical research as a Principal Investigator, Sub-Investigator, or equivalent role is advantageous.
• Experience working with pharmaceutical companies, biotechnology organisations, or CROs is desirable.
• Demonstrated interest in clinical innovation and therapeutic development.
• Strong collaboration and stakeholder management skills.
• Ability to travel periodically for business needs.

Preferred Background:

• Experience leading clinical research studies within metabolic or endocrine therapeutic areas.
• Exposure to obesity, diabetes, MASH/NASH, dyslipidaemia, or cardiovascular outcomes research.
• Scientific publications, conference presentations, or recognised clinical leadership.
• Established professional networks within research, healthcare, academia, or industry.
• Experience contributing to programme development, site expansion, or research growth initiatives.

Compensation Structure:

• Competitive physician salary plus productivity-based incentives.
• Opportunity to lead the company’s Cardiometabolic and Endocrinology research strategy.
• Direct engagement with pharmaceutical sponsors and industry partners.
• Potential leadership and long-term growth opportunities.

For more information, please contact William Tyler.

If you are interested in applying to this exciting opportunity, then please click ‘Apply’ or to speak to one of our specialists visit the ‘Contact Us’ page.

R&D Partners is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. R&D Partners is acting as an Employment Agency in relation to this vacancy.

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